HIV Neurotoxicity: Potential Therapeutic Interventions
نویسندگان
چکیده
منابع مشابه
HIV Neurotoxicity: Potential Therapeutic Interventions
Individuals suffering from human immunodeficiency virus type 1 (HIV-1) infection suffer from a wide range of neurological deficits. The most pronounced are the motor and cognitive deficits observed in many patients in the latter stages of HIV infection. Gross postmortem inspection shows cortical atrophy and widespread neuronal loss. One of the more debilitating of the HIV-related syndromes is A...
متن کاملApoptosis as a Potential Target in Therapeutic and Vaccine Interventions against Parasitic Diseases
Apoptosis is a physiological cell death that occurs under normal conditions in major biological processes, including the removal of old, damaged, extra, or harmful cells. It plays an important role in natural evolution, tissue homeostasis, removal of cells damaged or infected by viruses, and removal of immune cells activated against self-antigens. The purpose of this review was to examine the r...
متن کاملTherapeutic potential of HIV protease-activable CASP3
Development of a therapeutic application of CASP3/caspase 3/CPP32, an executor of apoptosis, has been challenging because regulation of its activation is complicated. This study aimed to inhibit cancer cell growth and human immunodeficiency virus type 1 (HIV-1) propagation through a CASP3 mutant, CASP3*, activable by HIV-1-encoded aspartate protease. Active CASP3* was delivered to leukemic cell...
متن کاملTherapeutic interventions for HIV infection and chronic viral hepatitis.
Combination antiretroviral therapy reduces overall and liver-specific morbidity and mortality in coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) and represents the most beneficial pharmaceutical treatment intervention for most coinfected patients. Antiviral therapy for HCV infection is potentially organ- and life-saving but, in general, should be reserved for pat...
متن کاملMitochondrial dysfunction in heart failure: potential for therapeutic interventions?
a , b,c * William C. Stanley , Charles L. Hoppel Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA Departments of Pharmacology and Medicine, Case Western Reserve University, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA Veterans Affairs Medical...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2006
ISSN: 1110-7243,1110-7251
DOI: 10.1155/jbb/2006/65741